Leshuk S.I., Annenkov V.V.,Danilovtseva E.N., Serdiuk L.V., Mazyar N.L., Shmeleva E.A., Mikhaleva A.I., Trofimov B.A. 2003. Immunoadjuvant activity of poly-1-vinylimidazole and method for preparing antibody raised to diphtheria corynebacterium based on thereof Patent RU 2205408.
FIELD: medicine, immunology.
SUBSTANCE: invention relates to application of poly-1-vinylimidazole as substance eliciting immunoadjuvant activity and method for preparing antibodies raised to diphtheria corynebacteria by administration of the preparation of cellular membranes of C. diphtheriae "Kodivak" in animal's body using poly-1-vinylimidazole in the concentration 0.01-0.6 mg/ml as an adjuvant. Invention can be used for preparing protective antibodies raised to bacteria C. diphtheriae in production of immune sera.
EFFECT: expanded assortment of adjuvant preparations, simplified method for preparing antibodies raised to C. diphtheriae, reduced cost.